反应详情

Solid 2-[2-(carbamoylmethoxy)-5-(chlorosulfonyl)phenoxy acetamide (Intermediate A85, 161.25 g, 0.5 mol) was added to a solution of p-anisidine (49.2 g, 0.4 mol) in pyridine (3.5 L) and stirred at room temperature overnight under argon. The reaction mixture was concentrated under reduce pressure. The residue was treated with 0.75 M hydrochloric acid (3 L) and the resulting solid was collected. The solid was washed with water (3×1 L), methanol (750 mL) and dried to give 99 g (60%) of the title compound, sulfonamide.

1. concentrationThe reaction mixture was concentrated
2. additionThe residue was treated with 0.75 M hydrochloric acid (3 L)
3. customthe resulting solid was collected
4. washThe solid was washed with water (3×1 L), methanol (750 mL)
5. customdried