3-Thiophenecarboxaldehyde → HCID 86604645, compound

HRID 1593314Notes

Reaction equation

[CH2:1]([O:8][C:9]([NH:11]/[C:12](=[CH:17]\[C:18]1SC=[CH:21][CH:22]=1)/[C:13]([O:15][CH3:16])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:23]1C=CC(C=O)=[CH:24]1>>[CH2:1]([O:8][C:9]([NH:11]/[C:12](=[CH:17]\[C:18]1[CH:22]=[CH:21][S:23][CH:24]=1)/[C:13]([O:15][CH3:16])=[O:14])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 681353-Thiophenecarboxaldehyde

HCID 15184928HCID 15184928, compound

Product 1

HCID 86604645HCID 86604645, compound

Procedure

A method similar to that used for the preparation of (99a) was used except that 3-thiophenecarboxaldehyde (762 mg) was used as the aldehyde component to afforded the desired product (549 mg). 1H NMR (300 MHz, CDCl3) δ 3.795 (s, 3H), 5.19 (s, 2H), 5.99 (br., 1H), 7.07 (m, 1H), 7.34(m, 7H), 7.49(d, 1H, J=5 Hz), 7.77(s, 1H). LC/MS: 2.32 min.

Sources & evidence

ORD record: ord-cefc8def46de4c54b9e9c9147afa1d6d
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07294622B2

Reaction notes

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