HCID 68604720, compound → HCID 69363083, compound

Participants

Reaction Steps

A method similar to the one described for (97) was used except that (2,3-cisS)-3-amino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrobromide (9d) (105 mg) was used as the amine component and N-[(3,5-difluorophenyl)acetyl]-3-(1H-indol-2-yl)-L-alanine (110b) (119 mg) was used as the acid component to afford the title compound as a 1:1 mixture with the 2S,3S diastereomer (173 mg), white solid, m.p.85-90° C. 1H NMR (300 MHz, d6-DMSO) δ 2.40 (m, 2H), 3.03 (m, 4H), 4.26 (m, 1H), 4.72 (m, 1H), 5.17(d, 1H, J=7 Hz), 5.82(d, 1H, J=6 Hz), 6.89-7.79 (m, 12H), 8.21(m, 1H), 10.53 (m, 1H). MS APCI, m/z=611(M+1). LC/MS: 2.66.min.

Provenance & Evidence