Hydrochloric Acid → HCID 66917896, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of {4-{4-[bis-(4-fluorophenyl)methyl]piperazin-1-yl}-(Z)-but-2-enyloxy}acetic acid (1.0 g, 0.0024 mol) in isopropyl alcohol (20 ml), is added a solution of anhydrous HCl in isopropyl alcohol till pH of solution is 1-2. The solution is refluxed for around 2 hrs, cooled to 25-30° C. and stirred for 4 hrs. The crystallized solid is filtered, washed with isopropyl alcohol (2×5 ml), and dried in oven at 60-65° C. to get product 0.968 g (75.85% yield).

Provenance & Evidence