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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1593377Generated: October 30, 2026

Potassium tert-butoxide → 4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-fluoro-6-methoxybenzonitrile

https://huagongshe.com/reaction/1593377

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium tert-butoxideHCID 23665647—
Reactant4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2,6-difluorobenzonitrileHCID 68691962—
Product4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-fluoro-6-methoxybenzonitrileHCID 68691170—

Reaction Steps

The compound was synthesized in the similar manner as in Reference Example 4-1 using 4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2,6-difluorobenzonitrile and 1 equivalent of potassium tert-butoxide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07297698B2
Source datasetuspto-grants-2007_11
ORD IDord-a0991420e7ee4ae0929b78f8c594acce
Source noteuspto-grants-2007_11