反应详情

In 30 ml of ethanol and 20 ml of a 1M sodium hydroxide aqueous solution, 2.9 g of ethyl 2-methylpyrimidine-5-carboxylate was stirred for 2 hours. The solvent was removed by evaporation and an appropriate amount of water and diethyl ether were added thereto, followed by liquid-separating operation. The resulting aqueous layer was made weakly acidic with a 1M hydrochloric acid aqueous solution and then the resulting crystals were collected by filtration, washed with water, and then dried to obtain 1.9 g of the title compound.

1. customThe solvent was removed by evaporation
2. additionan appropriate amount of water and diethyl ether were added
3. customby liquid-separating operation
4. filtrationthe resulting crystals were collected by filtration
5. washwashed with water
6. customdried