4-Cyanophenyl isocyanate → (2R,5S)-4'-Cyano-4-(4-cyano-3-fluoro-5-methoxyphenyl)-2,5-dimethylpiperazine-1-carboxanilide

HRID 1593390Notes

Reaction equation

HRID 1593390 reaction equation
[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C:9]1[CH:16]=[C:15]([O:17][CH3:18])[C:12]([C:13]#[N:14])=[C:11]([F:19])[CH:10]=1.[N:20]([C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1)=[C:21]=[O:22]>C(#N)C>[C:27]([C:26]1[CH:29]=[CH:30][C:23]([NH:20][C:21]([N:6]2[CH2:7][C@H:2]([CH3:1])[N:3]([C:9]3[CH:16]=[C:15]([O:17][CH3:18])[C:12]([C:13]#[N:14])=[C:11]([F:19])[CH:10]=3)[CH2:4][C@H:5]2[CH3:8])=[O:22])=[CH:24][CH:25]=1)#[N:28]

Participants

4

Reactant 2

HCID 1703804-Cyanophenyl isocyanateHCID 686911704-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-fluoro-6-methoxybenzonitrile

Product 1

HCID 68695786(2R,5S)-4'-Cyano-4-(4-cyano-3-fluoro-5-methoxyphenyl)-2,5-dimethylpiperazine-1-carboxanilideYield 69.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Into 20 ml of acetonitrile was dissolved 500 mg of 4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-fluoro-6-methoxybenzonitrile, and then 274 mg of 4-isocyanatobenzonitrile was added thereto, followed by 1 hour of stirring at room temperature. The reaction solution was concentrated, followed by addition of ethyl acetate and filtration. The filtrate was removed by evaporation and the resulting powder was crystallized from hexane-ethyl acetate (85:15, v/v) to obtain 535 mg of the title compound.

Workup

  1. concentrationThe reaction solution was concentrated
  2. additionfollowed by addition of ethyl acetate and filtration
  3. customThe filtrate was removed by evaporation
  4. customthe resulting powder was crystallized from hexane-ethyl acetate (85:15, v/v)

Sources & evidence

ORD record
ord-fe9b58de3b014ccba22663b3ada003ff
Source dataset
uspto-grants-2007_11
Patent number
US07297698B2

Reaction notes

Loading…