HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-nitroanisole → 4-Chloro-3-methoxyaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-nitroanisole | HCID 70519 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Chloro-3-methoxyaniline | HCID 13103692 | 92.6% |
Reaction Steps
A mixture of 36 g of 2-chloro-5-nitroanisole and Raney® nickel in 150 ml of MeOH and 200 ml of THF is hydrogenated in Par apparatus for 4 hours, at 35° C. and at a pressure of 1.3 bar. The catalyst is filtered off on Celite® and the filtrate is concentrated under vacuum. 28 g of the expected product are obtained, and are used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07297692B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-a14f2cd4d5374279ac1e8d3d79d7bb03 |
| Source note | uspto-grants-2007_11 |