Boron tribromide → HCID 136334111, compound

Participants

Reaction Steps

A solution of the product of Step 4 (100 mg, 0.26 mmol) in dichloromethane (2 ml) was treated at 0° C. with boron tribromide (1.3 ml of a 1M solution in dichloromethane, 1.3 mmol) and stirred at room temperature for 1 hour. The reaction mixture was poured into saturated sodium bicarbonate solution extracted into dichoromethane, dried (Na2SO4) and concentrated in vacuo. The residue was dissolved in methanol/dichloromethane and applied to an SCX column eluting with methanol and then a mixture of 0.880 ammonia/methanol (1:9). The basic fractions were combined and concentrated in vacuo to afford the title compound (65 mg, 70%); MS(ES+) m/e 368 [M+H]+.

Provenance & Evidence