HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (3S,4R)-ethyl 4-(allyloxycarbonyl)piperidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (3S,4R)-1-tert-butyl 3-ethyl 4-(allyloxycarbonyl)piperidine-1,3-dicarboxylate | HCID 66952501 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3S,4R)-ethyl 4-(allyloxycarbonyl)piperidine-3-carboxylate | HCID 86609246 | 37.1% |
Reaction Steps
A solution of 259B (680 mg, 1.9 mmol) in CH2Cl2 (10 mL) was treated with TFA (1 mL) at room temperature. The reaction mixture was stirred for 16 hours, then concentrated. The residues was dissolved in EtOAc (20 mL) and washed with saturated aqueous NaHCO3 (2×20 mL), dried (Na2SO4), filtered and concentrated in vacuo to afford 170 mg of Compound 259C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07297695B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-ed44aafa72904d74af1c1a510447dea6 |
| Source note | uspto-grants-2007_11 |