5-Chloro-1H-indole-2-carboxylic acid → HCID 69329746, compound

HRID 1593493Notes

Reaction equation

HRID 1593493 reaction equation
[CH3:1][S:2][CH2:3][C@H:4]([C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)=[O:7])[NH2:5].[Cl:21][C:22]1[CH:23]=[C:24]2[C:28](=[CH:29][CH:30]=1)[NH:27][C:26]([C:31](O)=[O:32])=[CH:25]2>>[ClH:21].[Cl:21][C:22]1[CH:23]=[C:24]2[C:28](=[CH:29][CH:30]=1)[NH:27][C:26]([C:31]([NH:5][C@@H:4]([C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH:14]3[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]3)[CH2:12][CH2:13]1)=[O:7])[CH2:3][S:2][CH3:1])=[O:32])=[CH:25]2

Participants

3

Reactant 2

HCID 826935-Chloro-1H-indole-2-carboxylic acidHCID 69329121HCID 69329121, compound

Product 1

HCID 69329746HCID 69329746, compound

Procedure

Prepared from 1-(S-methyl-D-cysteinyl)-4-(1-methyl-piperidin-4-yl)piperidine and 5-chloroindole-2-carboxylic acid using methods substantially equivalent to General Coupling Method 1. The HCl salt is prepared following General Salt Formation Method 1.

Sources & evidence

ORD record
ord-52c94638656547d8866dc76dbfd8ab12
Source dataset
uspto-grants-2007_11
Patent number
US07297706B2

Reaction notes

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