HCID 12146854, compound → 2-(1H-Pyrrolo[3,2-b]pyridin-3-yl)ethanamine

Participants

Reaction Conditions

Reaction Steps

A solution of 2-oxo-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)acetamide (1 eq.) in ether is treated with lithium aluminum hydride (4 eq.), heated at reflux temperature for 8 h, cooled to 0° C., quenched by addition of Rochelle's salt solution and extracted with CH2Cl2. The extracts are combined, dried over MgSO4 and concentrated to afford the title amine, which is used directly in the next step.

Provenance & Evidence