2-Chlorobenzothiazole → HCID 11189033, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.339 g (2 mmol) 2-Chlorobenzthiazole (commercially available) and 0.275 g (2 mmol) 3-methoxy-4-methylaniline (commercially available) in 4 ml acetic acid was heated to 115° C. for 4 h. After cooling to room temperature the mixture was subjected to preparative HPLC separation on reversed phase eluting with an acetonitrile/water gradient. The product fractions of Benzothiazol-2-yl-(3-methoxy-4-methyl-phenyl)-amine were evaporated to dryness and reacted according to the procedure described for Example 2 with 2-chlorobenzoyl chloride to yield the title compound. MS (m/e): 409.3 (MH+, 100%). According to the procedure described for Example 35 further N-Benzothiazol-2-yl-N-(aryl)-benzamide derivatives have been synthesised by reaction of 2-chlorobenzthiazole with the respective aniline (commercially available) and subsequently with the respective acid chloride. The results are shown in table 2 below and comprise Example 36 to Example 43.

Provenance & Evidence