Ammonia → HCID 53402441, compound

HRID 1593530Notes

Reaction equation

HRID 1593530 reaction equation
C(O[C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])[CH2:8][CH2:7]1)=[NH:5])C.[NH3:17]>>[Cl:16][C:10]1[CH:11]=[C:12]([Cl:15])[CH:13]=[CH:14][C:9]=1[C:6]1([C:4]([NH2:5])=[NH:17])[CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 69513897HCID 69513897, compound

Product 1

HCID 53402441HCID 53402441, compound

Procedure

The crude 1-(2,4-Dichloro-phenyl)cyclopropanecarboximidic acid ethyl ester was dissolved in a solution NH3 (2.0 M in EtOH; 40 mL). Anhydrous NH3 (g) was bubbled into the solution until it was apparently saturated (60 min). The reaction mixture was stirred for 4 days. The solvent was evaporated and the desired product recrystallized from Ethyl acetate. (350 mg, 31%).

Workup

  1. customAnhydrous NH3 (g) was bubbled into the solution until it
  2. custom(60 min)
  3. customThe solvent was evaporated
  4. customthe desired product recrystallized from Ethyl acetate

Sources & evidence

ORD record
ord-c429cc50ae1545dba2948f71f4fa8aa5
Source dataset
uspto-grants-2007_11
Patent number
US07297708B2

Reaction notes

Loading…