Dimethyl Sulfoxide → HCID 86619199, compound

HRID 1593539Notes

Reaction equation

HRID 1593539 reaction equation
Br[C:2]1(Br)[C:6]([O:7][CH3:8])=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:4]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=2[Cl:23])[NH:3]1.[OH2:25].[CH3:26]S(C)=O>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([C:5]2[N:4]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=3[Cl:23])[N:3]=[C:2]([CH:26]=[O:25])[C:6]=2[O:7][CH3:8])=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 66839338HCID 66839338, compound

Product 1

HCID 86619199HCID 86619199, compound

Conditions

Temperature
120 °C

Procedure

Under nitrogen, 5 g of the 3,3-dibromo-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methoxy-1H-pyrazole obtained in stage G is placed in 30 ml of DMSO, and it is heated at 120° C. for 6 hours. The reaction mixture is poured into 100 ml of water and it is extracted twice with 100 ml of AcOEt. The organic phase is washed with 100 ml of saturated NaCl and then dried over Na2SO4. After evaporating to dryness, 4 g of the unpurified expected compound is obtained.

Workup

  1. extractionis extracted twice with 100 ml of AcOEt
  2. washThe organic phase is washed with 100 ml of saturated NaCl
  3. dry with materialdried over Na2SO4
  4. customAfter evaporating to dryness

Sources & evidence

ORD record
ord-89c63e9c31fd4d679599d18f64b61c4d
Source dataset
uspto-grants-2007_11
Patent number
US07297710B1

Reaction notes

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