HuagongsheHuagongshe Chemistry Print Report · For research reference only
Monobenzone → Methyl 2-[4-(benzyloxy)phenoxy]butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Monobenzone | HCID 7638 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Butanoic acid, 2-bromo-, methyl ester | HCID 95577 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 2-[4-(benzyloxy)phenoxy]butanoate | HCID 68566999 | 91% |
Reaction Steps
A mixture of 4-benzyloxyphenol (30 g, 0.15 mol), cesium carbonate (58.6 g, 0.18 mol) and methyl 2-bromobutanoate (40.7 g, 0.22 mol) in CH3CN (350 mL) was kept at reflux for 20 hr. After cooling, the mixture was filtered and concentrated under reduced pressure and chromatographed over silica gel using AcOEt/hexanes to give the title compound 41.0 g (91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07297715B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-d6db58e0762f4d45962d68995492031f |
| Source note | uspto-grants-2007_11 |