Benzyl Alcohol → HCID 67206080, compound

Participants

Reaction Steps

To a solution of (3R)-6-Fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (0.60 g, 2.57 mmol) in anhydrous 1,4-dioxane (20 mL) was added diphenylphosphorylazide (0.7 mL, 3.24 mmol), triethylamine (0.39 mL, 2.83 mmol), and 4 A molecular sieves. After stirring at room temperature for 2 h, benzyl alcohol (0.8 mL, 7.71 mmol) was added and the reaction was heated at 70° C. for 2 h. After cooling, the mixture was filtered and the filtrate was concentrated in vacuo. Purification by chromatography on silica gel afforded 340 mg of the title compound as a colorless oil.

Provenance & Evidence