2-Chloro-5-(chloromethyl)pyridine → Imidacloprid

HRID 1593662Notes

Reaction equation

HRID 1593662 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Cl)=[CH:4][N:3]=1.[N+:10]([N:13]=[C:14]1[NH:18][CH2:17][CH2:16][NH:15]1)([O-:12])=[O:11]>>[CH:6]1[C:5]([CH2:8][N:15]2[CH2:16][CH2:17][NH:18]/[C:14]/2=[N:13]\[N+:10]([O-:12])=[O:11])=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 1554792-Chloro-5-(chloromethyl)pyridineHCID 135413413N-nitroimidazolidin-2-imine

Product 1

HCID 86287518Imidacloprid

Procedure

Preferably, the reaction of 2-chloro-5-chloromethyl pyridine with 2-nitroiminoimidazolidine is carried out at 50° C., so as to obtain good yields of imidacloprid.

Workup

  1. customis carried out at 50° C.
  2. customso as to obtain good

Sources & evidence

ORD record
ord-db3d0eb05b3145209128d3b794fc72ce
Source dataset
uspto-grants-2007_11
Patent number
US07297798B2

Reaction notes

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