Pyridine → HCID 178449913, compound

HRID 1593672Notes

Reaction equation

HRID 1593672 reaction equation
[C:1](Cl)(=[O:5])[CH2:2][CH2:3][CH3:4].[Br:7][C:8]1[CH:9]=[C:10]2[C:16](N)=[N:15][NH:14][C:11]2=[N:12][CH:13]=1.[N:18]1C=CC=CC=1>>[Br:7][C:8]1[CH:9]=[C:10]2[C:16]([CH:2]([CH2:3][CH3:4])[C:1]([NH2:18])=[O:5])=[N:15][NH:14][C:11]2=[N:12][CH:13]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 8855Butyryl chlorideHCID 178509224HCID 178509224, compound

Product 1

HCID 178449913HCID 178449913, compound

Procedure

Butyryl chloride (2.1 ml, 20.7 mmol) was added to a stirred solution of 5-bromo-1H-pyrazolo[3,4-b]pyridin-3-ylamine (4.0 g, 18.8 mmol) in pyridine (50 ml). The solution was heated at reflux for 12 hours then concentrated in vacuo. Addition of water afforded a solid which was filtered and dried to afford the title compound.

Workup

  1. temperatureThe solution was heated
  2. temperatureat reflux for 12 hours
  3. concentrationthen concentrated in vacuo
  4. additionAddition of water
  5. customafforded a solid which
  6. filtrationwas filtered
  7. customdried

Sources & evidence

ORD record
ord-53369640b11d4e88b5587c0ac07be162
Source dataset
uspto-grants-2007_11
Patent number
US07297792B2

Reaction notes

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