Hydrazinium chloride → HCID 178468624, compound

HRID 1593679Notes

Reaction equation

HRID 1593679 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9](=O)[CH2:10][C:11](O)([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:12](OCC)=[O:13].Cl.[NH2:25][NH2:26]>C(O)C>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[N:26]=[N:25][C:12]([OH:13])=[C:11]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:10]=1

Participants

4

Reactant 2

HCID 115031Hydrazinium chlorideHCID 21948264Diethyl 2-[2-(2,3-difluorophenyl)-2-oxoethyl]-2-hydroxymalonate

Product 1

HCID 178468624HCID 178468624, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Diethyl 2-[2-(2,3-difluorophenyl)-2-oxoethyl]-2-hydroxymalonate (18.50 g, 56.1 mmol) and hydrazine monohydrochloride (4.03 g, 58.8 mmol) were stirred at reflux in ethanol (300 mL) for 96 h, and then evaporated to dryness to afford the title compound as a solid.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-31c496e3f457487ba0bc418613b8e1c0
Source dataset
uspto-grants-2007_11
Patent number
US07297792B2

Reaction notes

Loading…