Ammonium formate → HCID 86608218, compound

Participants

Reaction Steps

A mixture of 1-benzyl-piperidine-4-carboxylic acid [5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyridazin-3-yl]-amide (Example 209; 340 mg, 0.76 mmol), ammonium formate (191 mg, 3.03 mmol) and 10% Pd/C (50 mg) in ethanol (10 mL) was stirred at reflux for 72 h. The reaction mixture was cooled, filtered through celite and concentrated. The residue was purified by chromatography on silica gel using initially 10% v/v methanol in dichloromethane and rising to 10% v/v 2N methanolic ammonia in dichloromethane to afford the title compound, a powder.

Provenance & Evidence