Dimethylformamide → DCCI HOBt

Participants

Reaction Steps

These reactions were done in a 96-well plate. The reagents are given per well. Sulfonamide benzoic acid IIIp (4 mg, 0.012 mmol) in 300 μl N,N-dimethylformamide and polystyrene-DCC resin (15 mg, loading ca. 1.27 mmol/g) were combined with HOBt (2 mg, 0.015 mmol) and amine B (0.010 mmol). The reaction was shaken for 24 h, then polystyrene-(polystyrene)-trisamine resin (9 mg, loading ca. 4.36 mmol/g) was added and shaken overnight. The reaction was filtered and the N,N-dimethylformamide evaporated.

Provenance & Evidence