3-Amino-1-propanol → Azd-9056

Participants

Reaction Steps

Sodium triacetoxyborohydride (1.86 g) was added to a solution of 2-chloro-5-(3-oxopropyl)-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide (1.57 g, Example 29b) and 3-amino-1-propanol (0.8 ml) in dichloromethane (150 ml). After 24 h the crude reaction mixture was purified by chromatography (eluting with 5-20% methanol in dichloromethane+1% ammonia) to give the subtitled compound as a white solid (1.05 g).

Provenance & Evidence