Piperidin-2-ylmethanol → HCID 21074072, compound

HRID 1593942Notes

Reaction equation

HRID 1593942 reaction equation
Cl[CH2:2][CH2:3][C:4]([NH:6][C:7]1[CH:20]=[CH:19][C:18]2[NH:17][C:16]3[C:11](=[CH:12][C:13]([NH:21][C:22](=[O:26])[CH2:23][CH2:24]Cl)=[CH:14][CH:15]=3)[C:10](=[O:27])[C:9]=2[CH:8]=1)=[O:5].[OH:28][CH2:29][CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][NH:31]1>>[OH:28][CH2:29][CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][N:31]1[CH2:2][CH2:3][C:4]([NH:6][C:7]1[CH:20]=[CH:19][C:18]2[NH:17][C:16]3[C:11](=[CH:12][C:13]([NH:21][C:22](=[O:26])[CH2:23][CH2:24][N:31]4[CH2:32][CH2:33][CH2:34][CH2:35][CH:30]4[CH2:29][OH:28])=[CH:14][CH:15]=3)[C:10](=[O:27])[C:9]=2[CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 94263Piperidin-2-ylmethanolHCID 21074075HCID 21074075, compound

Product 1

HCID 21074072HCID 21074072, compound

Procedure

Chloroamide 13 (1.0 g, 2.5 mmol) was treated with 2-hydroxymethylpiperidine (5 mL) according to the general aminolysis procedure to give the desired product JM-ACO-11 (888 mg, 63%) as a pale yellow/green solid.

Sources & evidence

ORD record
ord-1c8633e963cc494ba2fc2641d66a0bb6
Source dataset
uspto-grants-2007_11
Patent number
US07300930B2

Reaction notes

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