Sodium Hydroxide → HCID 86598716, compound

Participants

Reaction Steps

A mixture of 2-[6-chloro-2-pyrazinyl]-(1S,4S)-5-tert-butoxycarbonyl-2,5-diazabicyclo-[2.2.1]-heptane (10.6 g, 34.1 mmol), N-bromosuccinimide (6.06 g, 34.1 mmol) and acetonitrile (100 ml) was stirred for 3 hours. Aqueous sodium hydroxide (200 ml, 1 M) was added and the acetonitrile was evaporated. The mixture was extracted with ethyl acetate (2×200 ml). Chromatography on silica gel with ethyl acetate: petroleum (1:1) gave the title compound as free base. Yield 10.44 g (79%).

Provenance & Evidence