反应详情

The nitrile compound of step 3 (5.82 g, 20.68 mmol) was dissolved in 69 mL (0.3M) of formic acid and stirred at room temperature for 5 h to completion. The formic acid was evaporated and the residue partitioned between ethyl acetate and 1 N sodium hydroxide, repeating the extraction three times with fresh ethyl acetate. The organic layers were combined, dried over magnesium sulfate and concentrated to give 2.22 g of the crude (1R,2S)-2-amino-N-(cyanomethyl)cyclohexanecarboxamide.

1. customThe formic acid was evaporated
2. customthe residue partitioned between ethyl acetate and 1 N sodium hydroxide
3. extractionthe extraction three times with fresh ethyl acetate
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated