HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imatinib → Imatinib Mesylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imatinib | HCID 5291 | — |
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Imatinib Mesylate | HCID 123596 | — |
Reaction Steps
Imatinib free base (5.0 gm) is dissolved in chloroform (50 ml) at room temperature and then methanesulfonic acid (0.75 ml) is added. The contents are stirred for 5 hours at room temperature and separated crystals are filtered and dried to give 5.0 gm of imatinib mesylate form H1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07300938B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-ebcfea050767412caea6e9813efa7206 |
| Source note | uspto-grants-2007_11 |