Piperazine → 1-(Thiazol-2-yl)piperazine

Participants

Reaction Conditions

Reaction Steps

3.61 g (22.0 mmol) of 2-bromothiazole were dissolved in n-butanol (20 ml) together with 1.90 g (22.0 mmol) piperazine. The reaction solution was heated at 120° C. 3 h and stirred at RT a further 16 h. The precipitate formed was then filtered off and the filtrate was concentrated in vacuo. The residue was taken up in DCM, and a 1 M aq. sodium carbonate soln was added. After separation of the phases, the organic phase was dried over magnesium sulfate, filtered and concentrated in vacuo. A column chromatography (MeOH:DIPE 1:1) was carried out on the residue to give 1.06 g (6.3 mmol, 28% of theory) of 1-thiazol-2-ylpiperazine.

Provenance & Evidence