反应详情

1.02 g (5.0 mmol) of ethyl 2-bromothiazole-5-carboxylate and 4.31 g (50 mmol) of piperazine were dissolved in ethanol (20 ml) and the mixture was heated under reflux over a period of 4 h. The solution was then concentrated in vacuo, taken up in EA and washed successively with water and a satd aq. NaCl solution. Following drying of the organic phase over MgSO4, filtration and removal of solvent in vacuo there were obtained 1.12 g (4.6 mmol, 93%) of ethyl 2-piperazin-1-ylthiazole-5-carboxylate.

1. temperaturethe mixture was heated
2. temperatureunder reflux over a period of 4 h
3. concentrationThe solution was then concentrated in vacuo
4. washwashed successively with water
5. dry with materialFollowing drying of the organic phase over MgSO4, filtration and removal of solvent in vacuo