反应详情

温度

40 °C

5.33 g (15.6 mmol) of tert-butyl 4-(5-ethoxycarbonylthiazol-2-yl)piperazine-1-carboxylate [Precursor BBB60] were dissolved in ethanol together with 0.96 g (17.1 mmol) of KOH (100 ml) and stirred at 40° C. 4 h. The resulting precipitate was filtered off and dissolved in water. After this, the solution was adjusted to a pH<2 with 10% strength hydrochloric acid and extracted with chloroform. The organic phase was washed with water and a satd aq. NaCl soln and dried over MgSO4. After filtration and concentration in vacuo, 2.77 g (8.8 mmol, 56%) of tert-butyl 4-(5-carboxythiazol-2-yl)piperazine-1-carboxylate were obtained from the residue by recrystallization from diethyl ether.

1. custom4 h
2. filtrationThe resulting precipitate was filtered off
3. dissolutiondissolved in water
4. extractionextracted with chloroform
5. washThe organic phase was washed with water
6. dry with materiala satd aq. NaCl soln and dried over MgSO4
7. filtrationAfter filtration and concentration in vacuo