Methyl iodide → HCID 52949871, compound

Participants

Reaction Steps

A solution of 41 (10.4 mg, 0.022 mmol), MeI (24 μL, 0.389 mmol), and Ag2O (25 mg, 0.108 mmol) in CH3CN (1 mL) was heated at 80° C. for 24 h. The reaction mixture was filtered through celite and washed with CH2Cl2. The filtrate was concentrated in vacuo and purified by TLC (silica gel, 35% EtOAc/hexane) to provide a yellow oil. The oil was sonicated in 2:1 Et2O/hexane to provide the title compound as an off-white solid. 1H NMR (DMSO-d6) δ 0.88 (t, J=7.1 Hz, 3H), 1.21 (t, J=7.1 Hz, 3H), 1.87 (m, 2H), 3.20 (m, 2H), 3.21 (s, 3H), 3.52 (m, 8H), 3.72 (m, 4H), 4.17 (q, J=7.1 Hz, 2H), 6.77 (s, 1H), 7.40 (m, 2H), 7.46 (m, 3H). Mass Spectrum (ESI+) m/e=496.2 (M+H).

Provenance & Evidence