Propylamine → 3-Nitro-4-(propylamino)benzonitrile

Participants

Reaction Steps

To a stirring suspension of 4-chloro-3-nitrobenzonitrile (7.30 g, 40 mmol) in isopropanol (30 mL) is added n-propylamine (9.87 mL, 120 mmol). The mixture is stirred at room temperature for 5 h, and the solid is then collected by filtration to give 4-n-propylamino-3-nitrobenzonitrile as a yellow solid. 1H NMR (CDCl3) δ 8.51 (1H, q), 8.42 (1H, br s), 7.60 (1H, m), 6.91 (1H, d), 3.33 (2H, q), 1.84-1.74 (2H, m), 1.07 (3H, t). LRMS 206.3 (MH+).

Provenance & Evidence