反应详情

A mixture of 1-(4-amino-3-ethylamino-phenyl)-ethanone (300 mg, 1.69 mmol) and 2-chloroacetamidine hydrochloride (804 mg, 5.1 mmol) in acetonitrile (20 mL) is refluxed for 3 hours. Solvent is removed and the residue is treated with NaHCO3 (5%, 20 mL) and DCM (50 mL). The organic layer is separated and the aqueous layer is extracted with DCM (2×40 mL). The combined organic layers are dried and solvent removed to give 1-(2-Chloromethyl-3-ethyl-3H-benzoimidazol-5-yl)-ethanone.

1. temperatureis refluxed for 3 hours
2. customSolvent is removed
3. additionthe residue is treated with NaHCO3 (5%, 20 mL) and DCM (50 mL)
4. customThe organic layer is separated
5. extractionthe aqueous layer is extracted with DCM (2×40 mL)
6. customThe combined organic layers are dried
7. customsolvent removed