反应详情

200 mg (0.6 mmol) of 1-benzyl-3-(5-ethoxycarbonyl-2-furyl)indazole were dissolved in ethylene glycol and heated under reflux for 1.5 h. For work-up, the mixture was concentrated using a rotary evaporator and the crude product was chromatographed over silica gel using hexane/ethyl acetate (1:1). This gave 68 mg (31%) of the title compound. 1H-NMR (D6-DMSO): δ=3.72 (q, 2H, CH2—OH), 4.31 (t, 2H, CH2—C —OH), 4.93 (t, 1H, OH), 6.78 (s, 2H, CH2-phenyl), 7.23 (d, 1H, H-3′), 7.23-7.40 (m, 6H, phenyl-H, H-5), 7.50 (d, 1H, H-4′), 7.50 (t, 1H, H-6), 7.83 (d, 1H, H-7), 8.16 (d, 1H, H-4).

1. temperatureheated
2. temperatureunder reflux for 1.5 h
3. concentrationFor work-up, the mixture was concentrated
4. customa rotary evaporator
5. customthe crude product was chromatographed over silica gel