反应详情

7.7 g (25.3 mmol) of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole and 11 g (126.5 mmol) of activated manganese(IV) oxide in 200 ml of dry carbon tetrachloride were stirred under reflux for 4.5 h. For work-up, the mixture was filtered off with suction and the filtrate was washed with water, dried and concentrated using a rotary evaporator. The crude product was recrystallized from isopropanol. This gave 4.8 g (63%) of the title compound. m.p.: 108° C.

1. temperatureunder reflux for 4.5 h
2. filtrationFor work-up, the mixture was filtered off with suction
3. washthe filtrate was washed with water
4. customdried
5. concentrationconcentrated
6. customa rotary evaporator
7. customThe crude product was recrystallized from isopropanol