Aluminium lithium hydride → (2S,3S)-2-amino-3-ethyl-5,5,5-trifluoropentan-1-ol

Participants

Reaction Conditions

Reaction Steps

(2S,3S)-2-Azido-3-ethyl-5,5,5-trifluoro-pentanoic acid was dissolved in THF (5 mL) at 0° C. and lithium aluminum hydride (1 M solution in THF) (mL, 1 mmol) was added. The resulting solution was stirred at 40° C. for 2 h. The reaction was quenched by sequential addition of water (60 μL), 15% aqueous sodium hydroxide (60 μL), and water (150 μL) with vigorous stirring between each addition. The mixture was then filtered and concentrated to give (2S, 3S)-2-amino-3-ethyl-5,5,5-trifluoro-pentan-1-ol.

Provenance & Evidence