2-Chlorobenzaldehyde → HCID 178515540, compound

Participants

Role	Name	HCID	Charge
Reactant	2-Chlorobenzaldehyde	HCID 6996	—
Reactant	2,2-Dimethyl-1,3-dioxane-4,6-dione	HCID 16249	—
Reactant	Pyrazol-3-ylamine	HCID 74561	—
Solvent	Ethanol	HCID 702	—
Product	HCID 178515540	HCID 178515540	78.3%

Reaction Conditions

Temperature	65 °C

Reaction Steps

To a stirring solution of 5-aminopyrazole (2.0 g, 20.1 mmol) in EtOH (40 mL) was added 2-chlorobenzaldehyde (2.8 mL, 20.1 mmol), followed by Meldrum's Acid (2.9 g, 20.1 mmol). The reaction was heated to 65° C. After 16 hr, the reaction was cooled to room temperature, filtered, washed with EtOH, and dried under reduced pressure to give the title compound (3.9 g, 78% yield) as a colorless solid. LRMS m/z (APCI+) 248 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07300944B2
Source dataset	uspto-grants-2007_11
ORD ID	ord-83a7e480c7594970a0a5701247a0bb24
Source note	uspto-grants-2007_11