Methanol → HCID 135448247, compound

Participants

Reaction Steps

To 3-{3-[6-oxo-4-(2,4,5-trifluoro-phenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridin-3-yl]-cyclobutyl}-benzaldehyde (15 mg, 0.03 mmol) in THF:MeOH (3 mL 3:1) was added sodium borohydride (10 mg, 0.26 mmol). After 30 min, the reaction was quenched by the addition of 5 drops of aqueous NaOH (1N). The reaction mixture was concentrated under reduced pressure. Purification of this material was accomplished by preparative plated chromatography. The product band was collected, extracted with EtOAc, filtered, and concentrated to give the title compound. LRMS m/z (APCI+) 428 (M+1).

Provenance & Evidence