Acetone → HCID 58691417, compound

HRID 1594468Notes

Reaction equation

HRID 1594468 reaction equation
[NH:1]1[CH2:5][CH2:4][CH:3]([NH:6][C:7]2[C:12]([C:13]3[N:18]=[CH:17][N:16]=[C:15]([O:19][C:20]4[C:25]5[N:26]=[C:27]([NH:29][C:30](=[O:32])[CH3:31])[S:28][C:24]=5[CH:23]=[CH:22][CH:21]=4)[CH:14]=3)=[CH:11][CH:10]=[C:9]([C:33]([F:36])([F:35])[F:34])[N:8]=2)[CH2:2]1.[CH3:37][C:38]([CH3:40])=O>>[CH:38]([N:1]1[CH2:5][CH2:4][CH:3]([NH:6][C:7]2[C:12]([C:13]3[N:18]=[CH:17][N:16]=[C:15]([O:19][C:20]4[C:25]5[N:26]=[C:27]([NH:29][C:30](=[O:32])[CH3:31])[S:28][C:24]=5[CH:23]=[CH:22][CH:21]=4)[CH:14]=3)=[CH:11][CH:10]=[C:9]([C:33]([F:36])([F:34])[F:35])[N:8]=2)[CH2:2]1)([CH3:40])[CH3:37]

Participants

3

Reactant 2

HCID 180AcetoneHCID 58691372HCID 58691372, compound

Product 1

HCID 58691417HCID 58691417, compound

Procedure

N-(4-(6-(2-(Pyrrolidin-3-ylamino)-6-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide, Example 3(c), (30 mg, 0.06 mmol) was reacted with acetone (1 mL, 136 mmol, Aldrich) under the conditions of Example 3(d) to give the title compound as a yellow solid. MS (ESI, pos. ion.) m/z: 558 (M+1). Mp: 140-141° C.

Sources & evidence

ORD record
ord-61733505b5674782a00bbed18c1b5092
Source dataset
uspto-grants-2007_11
Patent number
US07301022B2

Reaction notes

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