HCID 86607083, compound → HCID 58691334, compound

HRID 1594470Notes

Reaction equation

HRID 1594470 reaction equation
Cl.[CH2:2]([N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[C:12]#[C:13][C:14]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:16][C:15]=1[C:24]1[N:29]=[CH:28][N:27]=[C:26]([O:30][C:31]2[C:36]3[N:37]=[C:38]([NH:40][C:41](=[O:43])[CH3:42])[S:39][C:35]=3[CH:34]=[CH:33][CH:32]=2)[CH:25]=1)[CH:3]([CH3:5])[CH3:4]>O1CCOCC1>[CH2:2]([N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[CH2:12][CH2:13][C:14]1[CH:19]=[C:18]([C:20]([F:22])([F:23])[F:21])[CH:17]=[CH:16][C:15]=1[C:24]1[N:29]=[CH:28][N:27]=[C:26]([O:30][C:31]2[C:36]3[N:37]=[C:38]([NH:40][C:41](=[O:43])[CH3:42])[S:39][C:35]=3[CH:34]=[CH:33][CH:32]=2)[CH:25]=1)[CH:3]([CH3:5])[CH3:4]

Participants

3

Reactant 1

HCID 86607083HCID 86607083, compound

Product 1

HCID 58691334HCID 58691334, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of N-(4-(6-(2-(2-(1-isobutylpiperidin-2-yl)ethynyl)-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide hydrochloride, Example 15(c), (221 mg, 0.37 mmol) in dioxane (5 mL) was hydrogenated under the conditions of Example 12(a) to provide the title compound as a tan solid. MS (ESI, pos. ion) m/z: 598 (M+1).

Sources & evidence

ORD record
ord-77d3ca8e34314536af6bf22bf5842a13
Source dataset
uspto-grants-2007_11
Patent number
US07301022B2

Reaction notes

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