HCID 21865124, compound → HCID 58691402, compound

HRID 1594471Notes

Reaction equation

HRID 1594471 reaction equation
[CH3:1][CH:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:10][C:9]=1B(O)O.I[C:22]1[N:27]=[CH:26][N:25]=[C:24]([O:28][C:29]2[C:34]3[N:35]=[C:36]([NH2:38])[S:37][C:33]=3[CH:32]=[CH:31][CH:30]=2)[CH:23]=1>>[CH3:1][CH:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:10][C:9]=1[C:22]1[N:27]=[CH:26][N:25]=[C:24]([O:28][C:29]2[C:34]3[N:35]=[C:36]([NH2:38])[S:37][C:33]=3[CH:32]=[CH:31][CH:30]=2)[CH:23]=1

Participants

3

Reactant 2

HCID 21865124HCID 21865124, compoundHCID 58691323HCID 58691323, compound

Product 1

HCID 58691402HCID 58691402, compound

Procedure

2-((2-Methylpyrrolidin-1-yl)-methyl)-4-(trifluoromethyl)phenylboronic acid, Example 19(b), (72 mg, 0.25 mmol) and 4-(6-iodopyrimidin-4-yloxy)benzo[d]thiazol-2-amine (93 mg, 0.25 mmol, prepared as described in WO04014871) was reacted under conditions of Example 19(f) to give the title compound. MS (ESI, pos. ion.) m/z: 486 (M+1).

Sources & evidence

ORD record
ord-578c58b7c35f46b1a15e47994da02df1
Source dataset
uspto-grants-2007_11
Patent number
US07301022B2

Reaction notes

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