Sodium Iodide → HCID 58691336, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-(4-(6-(2-hydroxy-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)-acetamide (89 mg, 0.2 mmol, prepared as described in WO04014871), 2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride (56 mg, 0.3 mmol, Aldrich), sodium carbonate (62 mg, 0.6 mmol, Aldrich), sodium iodide (45 mg, 0.3 mmol) and acetone (1 mL) was heated in a microwave synthesizer at 150° C. for 40 min. The reaction mixture diluted with water (10 mL) and extracted with EtOAc (2×20 mL). The combined organic extracts were washed with brine, dried over Na2SO4, filtered, and evaporated in vacuo. The residue was purified by silica gel column chromatography (10% MeOH/CH2Cl2) to give the title compound as an amorphous solid. MS (ESI, pos. ion.) m/z: 558 (M+1).

Provenance & Evidence