Acetic Anhydride → HCID 58691396, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(6-(2-(((1-isobutylpiperidin-2-yl)methyl)(methyl)amino)-6-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yloxy)benzo[d]thiazol-2-amine, Example 24(d), (0.14 g, 0.24 mmol) and acetic anhydride (5 mL, Aldrich) in pyridine (20 mL) was stirred at 25° C. for 24 h. The reaction mixture was partitioned between aqueous solution of NaHCO3 and EtOAc. The organic phase was separated, washed with brine, dried over Na2SO4, filtered and evaporated under reduced pressure. Purification of the residue by silica gel column chromotography (gradient: 50-100% EtOAc/hexane) afforded the title compound as a yellow solid. MS (ESI, pos. ion.) m/z: 614 (M+1). Mp: 123.2-125.4° C.

Provenance & Evidence