tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate → HCID 58691315, compound

HRID 1594474Notes

Reaction equation

HRID 1594474 reaction equation
[NH2:1][CH2:2][C@@H:3]1[CH2:8][CH2:7][CH2:6][CH2:5][N:4]1[C:9](OC(C)(C)C)=O.Cl[C:17]1[C:22]([C:23]2[N:28]=[CH:27][N:26]=[C:25]([O:29][C:30]3[C:35]4[N:36]=[C:37]([NH2:39])[S:38][C:34]=4[CH:33]=[CH:32][CH:31]=3)[CH:24]=2)=[CH:21][CH:20]=[C:19]([C:40]([F:43])([F:42])[F:41])[N:18]=1>>[CH2:9]([N:4]1[CH2:5][CH2:6][CH2:7][CH2:8][C@H:3]1[CH2:2][NH:1][C:17]1[C:22]([C:23]2[N:28]=[CH:27][N:26]=[C:25]([O:29][C:30]3[C:35]4[N:36]=[C:37]([NH:39][C:25](=[O:29])[CH3:24])[S:38][C:34]=4[CH:33]=[CH:32][CH:31]=3)[CH:24]=2)=[CH:21][CH:20]=[C:19]([C:40]([F:43])([F:42])[F:41])[N:18]=1)[CH:19]([CH3:40])[CH3:20]

Participants

3

Reactant 2

HCID 1502020tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylateHCID 58691428HCID 58691428, compound

Product 1

HCID 58691315HCID 58691315, compound

Procedure

The title compound was prepared from (S)-2-aminomethyl-N-Boc-piperidine (AstaTech) and 4-(6-(2-chloro-6-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yloxy)-benzo[d]thiazol-2-amine, Example 1(b), analogous to the procedures described for Example 3(a-d). MS (ESI, pos. ion.) m/z: 600 (M+1).

Sources & evidence

ORD record
ord-c7b42d298fe84090b705fed02247b285
Source dataset
uspto-grants-2007_11
Patent number
US07301022B2

Reaction notes

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