HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58691367, compound → Carbon Dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58691367 | HCID 58691367 | — |
| Reactant | HCID 58691435 | HCID 58691435 | — |
| Product | Carbon Dioxide | HCID 280 | — |
| Product | HCID 58691388 | HCID 58691388 | — |
| Product | HCID 86607085 | HCID 86607085 | — |
Reaction Steps
(2S)-N-(2-(6-(2-Aminoquinolin-8-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)-phenyl)-1-isobutylpiperidine-2-carboxamide and (2R)-N-(2-(6-(2-Aminoquinolin-8-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-isobutylpiperidine-2-carboxamide. Chiral separation (Chiralpak ADH (250×21 mm, 5μ), A: liquid CO2, B: ethanol:acetonitrile:diethylamine (50:50:0.2), isocratic: 60:40 A:B, 60 mL/min, 24 mg/injection) of N-(2-(6-(2-aminoquinolin-8-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-isobutylpiperidine-2-carboxamide (Example 39) afforded the title compounds. MS (ESI, pos. ion.) m/z: 565 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07301022B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-ba0a43c00cac44e0a7930997b9226ca4 |
| Source note | uspto-grants-2007_11 |