Acetone → HCID 58691350, compound

HRID 1594479Notes

Reaction equation

[C:1]([NH:4][C:5]1[S:6][C:7]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][C:15]3[N:20]=[CH:19][N:18]=[C:17]([C:21]4[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=4[NH:31][C:32]([CH:34]4[CH2:39][CH2:38][CH2:37][CH2:36][NH:35]4)=[O:33])[CH:16]=3)[C:8]=2[N:9]=1)(=[O:3])[CH3:2].[CH3:40][C:41]([CH3:43])=O>>[C:1]([NH:4][C:5]1[S:6][C:7]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][C:15]3[N:20]=[CH:19][N:18]=[C:17]([C:21]4[CH:26]=[CH:25][C:24]([C:27]([F:29])([F:30])[F:28])=[CH:23][C:22]=4[NH:31][C:32]([CH:34]4[CH2:39][CH2:38][CH2:37][CH2:36][N:35]4[CH:41]([CH3:43])[CH3:40])=[O:33])[CH:16]=3)[C:8]=2[N:9]=1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 180Acetone

HCID 58691320HCID 58691320, compound

Product 1

HCID 58691350HCID 58691350, compound

Procedure

N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-piperidine-2-carboxamide, Example 49(a), (0.40 g, 0.72 mmol) was reacted with acetone under the conditions of Example 3(d) to give the title compound. MS (ESI, pos. ion.) m/z: 599 (M+1). Mp: 260° C. (with dec.).

Sources & evidence

ORD record: ord-219f48624467435181a04d55e9a3e238
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07301022B2

Reaction notes

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