HCID 58691359, compound → HCID 58691309, compound

Participants

Reaction Steps

(2R)-N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-isobutylpiperidine-2-carboxamide and (2S)-N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-isobutylpiperidine-2-carboxamide. Chiral separation [Chiralcel OD-H (250×21 mm, 5μ), A: hexane (0.2% diethylamine), B: ethanol (0.2% diethylamine), isocratic: 60:40 A:B, 20 mL/min] of N-(2-(6-(2-acetamidobenzo[d]-thiazole-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-isobutylpiperidine-2-carboxamide (Example 51) afforded the title compounds as amorphous solids. MS (ESI, pos. ion) m/z: 613 (M+1).

Provenance & Evidence