HRID1594484

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1[C@@H](c2ccccc2)CC[C@H]1C(=O)O

HCID2755972

(5R)-1-(tert-Butoxycarbonyl)-5-phenyl-L-proline

C16H21NO4

结构：CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4N)ncn3)cccc2s1

HCID21865046

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4NC(=O)[C@@H]4CC[C@H](c5ccccc5)N4C(=O)OC(C)(C)C)ncn3)cccc2s1

HCID58691342

未命名化合物

PROCEDURE

实验过程

(2S,5R)-1-(tert-Butoxycarbonyl)-5-phenylpyrrolidine-2-carboxylic acid (350 mg, 1.2 mmol, Neosystem-T) was reacted with N-(4-(6-(2-amino-4-(trifluoromethyl)-phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide (446 mg, 1.0 mmol, prepared as described in WO04014871) under the conditions of Example 45(a) to give the title compound as a white solid. MS (ESI, neg. ion.) m/z: 719 (M−1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-34caca6864664b61a9d37aea3b8ba8d2
来源数据集: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07301022B2
来源说明: uspto-grants-2007_11

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[C@@H:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:11][CH2:10][C@H:9]1[C:19](O)=[O:20])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:22][C:23]1[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[CH:25][C:24]=1[C:33]1[N:38]=[CH:37][N:36]=[C:35]([O:39][C:40]2[C:45]3[N:46]=[C:47]([NH:49][C:50](=[O:52])[CH3:51])[S:48][C:44]=3[CH:43]=[CH:42][CH:41]=2)[CH:34]=1>>[C:50]([NH:49][C:47]1[S:48][C:44]2[CH:43]=[CH:42][CH:41]=[C:40]([O:39][C:35]3[N:36]=[CH:37][N:38]=[C:33]([C:24]4[CH:25]=[CH:26][C:27]([C:29]([F:32])([F:30])[F:31])=[CH:28][C:23]=4[NH:22][C:19]([C@@H:9]4[CH2:10][CH2:11][C@H:12]([C:13]5[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=5)[N:8]4[C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[O:20])[CH:34]=3)[C:45]=2[N:46]=1)(=[O:52])[CH3:51]