HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2S,5R)-N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-5-phenylpyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2S,5R)-tert-Butyl 2-((2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)carbamoyl)-5-phenylpyrrolidine-1-carboxylate | HCID 58691342 | — |
| Product | (2S,5R)-N-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-5-phenylpyrrolidine-2-carboxamide | HCID 58691316 | — |
Reaction Steps
(2S,5R)-tert-Butyl 2-((2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)carbamoyl)-5-phenylpyrrolidine-1-carboxylate, Example 58, (575 mg, 0.8 mmol) was reacted with TFA under the condition of Example 3(c) to give the title compound as a white solid. MS (ESI, pos. ion.) m/z: 619 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07301022B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-69438084770a46ca8fe3a431bb7b8650 |
| Source note | uspto-grants-2007_11 |