HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-[2-[6-[[2-(Acetylamino)-4-benzothiazolyl]oxy]-4-pyrimidinyl]-5-(trifluoromethyl)phenyl]-5,5-dimethyl-2-pyrrolidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 58691423 | HCID 58691423 | — |
| Product | N-[2-[6-[[2-(Acetylamino)-4-benzothiazolyl]oxy]-4-pyrimidinyl]-5-(trifluoromethyl)phenyl]-5,5-dimethyl-2-pyrrolidinecarboxamide | HCID 44580333 | — |
Reaction Steps
The title compound was prepared by reacting tert-butyl 5-((2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)carbamoyl)-2,2-dimethylpyrrolidine-1-carboxylate [Example 59 (g)] with TFA under the condition of Example 3(c). MS (ESI, pos. ion.) m/z: 619 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07301022B2 |
| Source dataset | uspto-grants-2007_11 |
| ORD ID | ord-b9ad85e2c0bf40a48766b664ef0540a9 |
| Source note | uspto-grants-2007_11 |